Endocrine Abstracts

Introduction: Central obesity is the source of inflammatory factors, causing endothelial dysfunction. In central nervous system, inflammatory factors mediate neurotransmitter metabolism promoting excitotoxicity and increase oxidative stress, and a major clinical symptom is depression. Mediterranean diet (MD) resulted as a good prevention method for depression.Aim: To examine the relationship of depression with abdominal obesity and metabolic syndrome (MS...

Background: Abdominal obesity, which in fact is a metabolic syndrome (MS), is related to decreased testosterone, insulin resistance (IR), increased inflammatory factors, non-alcoholic fat liver disease (NAFLD) and risk of early atherosclerosis. Elevated inflammatory markers (CRP) may interfere with insulin signal transduction at the neuronal level inducing hypogonadotropic hypogonadism.Objective: To examine testosterone relationship with abdominal obesit...

Objective: It has been difficult to identify factors that affect the risk of cancer but we know that people are at higher risk as they get older, or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood.Aim: To study associations between PA and family history of malignancy in first-degree and second-degree relatives. As separate analysis, to study associations between PA patients...

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

Background: Obesity is followed by insulin resistance (IR) and low grade inflammation. In patients with metabolic syndrome (MS) and clinicaly evident vascular complications homocystein values are higher. Hyperhomocysteinemia correlates with hyperinsulinemia and IR, resulting in oxidative stress, which causes endothelial lesions and dysfunction, promoting atherosclerosis and hypertension.Objectives: To examine homocystein levels in patients with and witho...

It is well known that Romani people suffer from respiratory and cardiovascular diseases. The aim of our study was to investigate the prevalence of diabetes in the Romani population in Serbia.Methods: During the period October 2006–May 2008, diabetes association of Serbia performed blood glucose measurements in 11 urban and 8 rural Romani communities in Serbia. Blood glucose values, name, age, presence of diabetes, family history for diabetes, time o...

Background and aim: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionary conserved and widely distributed throughout organism. Broad interest for AIP comes from involvement of loss-of-function AIP mutations in pituitary adenoma pathogenesis. The role of AIP in normal pituitary function is largely unknown. AIP is co-localized with GH in somatotroph secretory vesicles. Serum AIP protein was proteomically identified. We aimed at investigating whether AIP and GH are...

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

Transition from childhood to adulthood is particularly important in patients with COGHD mainly because of the associated metabolic abnormalities, inadequate body composition and decreased bone mineral density (BMD). There is a lack of large monocentric studies related to this issue.Design: Monocentric, observational, retrospective cross-sectional study.Patients: We collected 85 COGHD patients (58 males, aged 17–26 years) trans...

Previous studies reported increased prevalence of metabolic syndrome (MS) and mortality rates from cardiovascular causes in hypopituitary patients. Fatty liver disease was added recently to this unfavorable cardio-metabolic phenotype. We studied the prevalence of MS and non-alcoholic fatty liver disease (NAFLD) in unselected cohort of 282 hypopituitary patients (146 male), mean age 49.2±15.1 years, on standard replacement therapy (76.4% received l-thyroxin, 76% hydrocorti...